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Liste referierter Publikationen


1) Lauster, R.: Antikörper gegen die Methyltransferase des temperenten Bacillus subtilis Phagen SPR (1984). Diplomarbeit Freie Universität Berlin.

2) Günthert, U., Reiners, L. and Lauster, R.: Cloning and expression of Bacillus subtilis phage DNA methyltransferase genes in Escherichia coli and B. subtilis (1986). Gene 41, 261-270.

3) Günthert, U., Lauster, R. and Reiners, L.: Multispecific DNA methyltransferases from Bacillus subtilis phages: Properties of wild-type and various mutant enzymes with altered DNA affinity (1986). Eur. J. Biochem. 159, 485-492.

4) Behrens, B., Noyer-Weidner, M., Pawlek, B., Lauster, R., Balganesh, T. S. and Trautner, T. A.: Organization of multispecific DNA methyl-transferases encoded by temperate B. subtilis phages (1987). EMBO J. 6, 1137-1142.

5) Lauster, R., Kriebardis, A. and Guschlbauer, W.: The GATATC modification enzyme EcoRV is closely related to the GATC recognizing methyltransferases DpnII and Dam from E.coli and phage T4 (1987). FEBS letters 220, 167-176.

6) Balganesh, T. S., Reiners, L., Lauster, R., Noyer-Weidner, M., Wilke, K. and Trautner, T. A.: Construction and use of chimeric DNA methyltransferases in the definition of sequence recognizing enzyme regions (1987). EMBO J. 6, 3543-3549.

7) Lauster, R.: DNA Methyltransferasen temperenter Bacillus subtilis Phagen: Biochemische und phylogenetische Untersuchungen als Beitrag zur Domänencharakterisierung (1987). Doktorarbeit Freie Universität Berlin.

8) Wilke, K., Rauhut, E., Noyer-Weidner, M., Lauster, R., Pawlek, B., Behrens, B. and Trautner, T. A.: Sequential order of target recognizing domains in multispecific DNA methyltransferases (1988). EMBO J. 7, 2601-2609.

9) Trautner, T. A., Balganesh, T. S., Wilke, K., Noyer-Weidner, M., Rauhut E., Lauster, R., Behrens, B. and Pawlek, B.: Organization of target recognizing domains in the multispecific DNA (cytosine 5) methyltransferases of Bacillus subtilis phages SPR and o3T (1988). Gene 74, 243.

10) Lauster, R.: Duplication and variation as a phylogenetic principle of type II methyltransferases (1988) Gene 74, 243.

11) Lauster, R., Trautner, T. A. and Noyer-Weidner, M.: Cytosine specific type II DNA methyltransferases. A conserved enzyme core with variable target recognizing domains (1989). J. Mol. Biol. 206, 305-312.

12) Lauster, R.: Evolution of type II restriction and modification enzymes. A gene duplication model (1989). J. Mol. Biol. 206, 313-321.

13) Lauster, R.: Close relationship between the HinfI and the DpnA methyltransferases (1989). Nucl. Acids Res. 17, 4402.

14) Chen, U., Kosko, M., D´Hostelaere, L. and Lauster, R. : Differentation of ES cells to lympho hematopoetic lineages (1990). Annual Report Basel Institute for Immunology.

15) Thiesen, H. J., Casorati, G., Lauster, R. and Wiles, M.: Application of Polymerase chain reaction (PCR) in molecular immunology (1990); in Levkovitz, I. and Pernis, B. (eds) Immunological methods IV, Academic Press 35-60.

16) Lauster, R., Reynaud, C. A., Martensson, L., Peter, A., Bucchini, D., Jami, J. and Weill, J. C.: Promoter, enhancer and silencer elements regulate rearrangement of an immuno-globulin transgene (1993). EMBO J. 12, 4615-4623.

17) Ferradini, L., Reynaud, C. A., Lauster, R. and Weill, J. C.: Rearrangement of the chicken lamda light chain locus: a silencer/ antisilencer regulation (1994). Seminars in Immunology 6, 165- 173.

18) Bulfone Paus, S., Reiners Schramm, L. and Lauster, R.: The chicken immunoglobulin lambda light chain gene is transcriptionally controlled by a modularly organized enhancer and an octamer dependent silencer (1995). Nucl. Acids Res. 23, 1997-2005.

19) Guardiola; J., Maffei, A., Lauster, R., Mitchison, N. A., Accolla, R. S and Sartoris: Functional significance of polymorphism among MHC class II gene promoters. (1996) tissue antigens 48, 615-625.

20) Kuon, W., Lauster, R., Böttcher, U., Koroknay, A., Ulbrecht, M., Grolms, M., Ugrinovic, S., Braun, J., Weiss, E. H. and Sieper, J.: Cytotoxic T cell response to Chlamydia trachomatis in HLA-B 2705 and human beta 2-microglobulin expressing homocygous transgenic CBA (H-2k) mice (1997) Arthritis Rheum 40, 945-954.

21) Janitz, M., Mitchison, A., Reiners-Schramm, L. and Lauster, R.: Polymorphic MHC class II promoters exhibit distinct expression pattern in various antigen presenting cell lines. (1997) tissue antigens 49, 99-106.

22) Bayrak, S., Holmdahl, R., Travers, P., Lauster, R., Hesse, M., Dölling, R. and Mitchison, N. A.: T cell response of I-Aq mice to self type II collagen: meshing of the binding motif of the I-Aq molecule with repetitive sequence results in autoreactivity to multiple epitopes (1997) Int. Immunology 9, 1687-1699.

23) Janitz, M., Böttcher, U., Landt, O. and Lauster, R.: Three alternatively spliced variants of the gene coding for the human bone morphogenic protein BMP-1 (1998) J. Mol. Med. 76, 141-146

24) Janitz, M., Reiners-Schramm, L. and Lauster, R.: Detection of enhancer activity in the 5´untranslated region of the I-Eb gene (1997) Immunogenetics 45, 432-435.

25) Ugrinovic, S., Mertz, A., Lauster, R. and Sieper, J.: Conserved bacterial proteins: Implications for the pathogenesis of reactive arthritis (1997) in Lukic, M., Colic, M., Mostarica-Stojkovic, M., Cuperlovic, K. (eds) Immunoregulation in health and disease, Academic press, 383-395.

26) Mertz, A. K. H., Ugrinovic, S., Lauster, R., Wu, P., Grolms, M., Böttcher, U., Appel, H., Yin, Z., Schiltz, E., Batsford, S., Schauer-Petrowski, C., Braun, J., Distler, A and Sieper. J.: Characterization of the synovial T-cell response to various recombinant Yersinia antigens in Yersinia-triggert reactive arthritis: conserved regions within the hsp60 drive a major immune response (1998) Arthr. Rheum. 41, 315-326.

27) Cowell. L., Kepler, T., Janitz, M., Lauster, R., and Mitchison, N. A.: The distribution of variation in regulatory gene segments, as seen in MHC class II promoters (1998) Genome Res. 8, 124-134.

28) Janitz, M., Reiners-Schramm, L. and Lauster, R.: Expression of the Ea gene is modulated by a polymorphic transcriptional enhancer (1998) Immunogenetics 48, 266-272.

29) Botchkarev, V., Botchkareva, N. V., Roth, W., Nakamura, M., Chen, L. H., Herzog, W., Lindner, G., McMahon, J., Peters, C., Lauster, R., McMahon, A. and Paus, R.: Noggin acts as a mesenchymally derived stimulator of hair follicle induction (1999) Nature Cell Biology 1, 158-164

30) Mertz, A. K. H., Wu, P., Sturniolo, T., Stoll, D., Rudwaleit, M., Lauster, R., Braun, J. and Sieper, J.: Multispecific CD4+ T-Cell Response to a single 12-mer Epitope of the immunodominant Heat-Shock Protein 60 of Yersinia enterocolitica in Yersinia-triggered reactive Arthritis: overlap with the B27-restricted CD8-epitope, functional properties and epitope presentation by multiple DR-alleles (2000) J. Immunol. 164, 1529-1537.

31) Scheffold, A., Assenmacher, M., Reiners-Schramm, L., Lauster, R. and Radbruch, A.: High sensitive immunofluorescence for detection of the pro- and anti-inflammatory cytokines IFN-gamma and Il-10 on the surface of cytokine secreting cells (2000) Nature Medicine 6, 107-110.

32) Pinto YM, Pinto-Sietsma SJ, Philipp T, Engler S, Kobetamehl P, Hocher B, Marquardt H, Sethmann S, Lauster R, Merker HJ, Paul M. Reduction in left ventricular messenger RNA for transforming growth factor beta(1) attenuates left ventricular fibrosis and improves survival without lowering blood pressure in the hypertensive TGR(mRen2)27 Rat. (2000) Hypertension 36, 747-54.

33) Thiel A, Wu P, Lauster R, Braun J, Radbruch A, Sieper J. Analysis of the antigen-specific T cell response in reactive arthritis by flow cytometry (2000). Arthritis Rheum. 43: 2834-42.

34) Botchkarev VA, Botchkareva NV, Nakamura M, Huber O, Funa K, Lauster R, Paus R, Gilchrest BA. Noggin is required for induction of the hair follicle growth phase in postnatal skin (2001) FASEB J. 15, 2205-221

35) Kuon W, Holzhütter HG, Appel H, Grolms M, Kollenberger S, Traeder A, Henklein P, Weiss E, Thiel A, Lauster R, Bowness P, Radbruch A, Kloetzel PM and Sieper J. Identification of HLA-B-27 restricted peptides from the Chlamydia trachomatis proteome with possible relevance to HLA-B-27 associated diseases. (2001) J. Immunol. 167, 4738-474.

36) Janitz M, Reiners-Schramm L, Muhlethaler-Mottet A, Rosowski M., Lauster R. Analysis of the sequence polymorphism within class II transactivator gene promoters (2002) Experimental and Clinical Immunogenetics 18, 199-205.

37) Zou J, Rudwaleit M, Thiel A, Lauster R, Braun J, Sieper J. T cell response to human HSP60 and yersinia 19 kDa in ankylosing spondylitis and rheumatoid arthritis: no evidence for a causal role of these antigens in the pathogenesis. (2002) Ann Rheum Dis. 61, 473-474.

38) Nakamura M, Matzuk MM, Gerstmayer B, Bosio A, Lauster R, Miyachi Y, Werner S, Paus R. Control of pelage hair follicle development and cycling by complex interactions between follistatin and activin. (2003) FASEB J. 17, (3) 497-499.

39) Bartholome B, Spies CM, Gaber T, Schuchmann S, Berki T, Kunkel D, Bienert M, Radbruch A, Burmester GR, Lauster R, Scheffold A, Buttgereit F. Membrane glucocorticoid receptors (mGCR) are expressed in normal human peripheral blood mononuclear cells and up-regulated after in vitro stimulation and in patients with rheumatoid arthritis. (2004) FASEB J. 18, 70-80.

40) Minina E, Schneider S, Rosowski M, Lauster R and Vortkamp A. Expression of Fgf and Tgfß signaling related genes during embryonic endochondral ossification. (2005) Gene Expr. Patterns 6, 102-109.

41) “Full check up” and “A new tooth instead of a set of spare teeth” in “Biotechnology 2020”, from the transparent cell to the custom designed process, published by the Europeam Commision, Community research (2006)16-19 and 24-27.

42) Spies CM, Schaumann DH, Berki T, Mayer K, Jakstadt M, Huscher D, Wunder C, Burmester GR, Radbruch A, Lauster R, Scheffold A, and Buttgereit F Membrane glucocorticoid receptors (mGCR) are down- regulated by glucocorticoids in patients with systemic lupus erythematosus and use a caveolin-1 independent expression pathway (2006) Ann Rheum Dis. 65, 1139-46

43) Rosowski M, Falb M, Tschirschmann M, Lauster R. Initiation of Mesenchymal condensation in Alginate Hollow Spheres- A useful model for understanding cartilage repair. (2006) Artificial Organs 30, 775-784

44) Schaumann DH, Tuischer J, Ebell ., Manz R, Lauster R. VCAM-1-positive stromal cells from human bone marrow producing cytokines for B lineage progenitors and for plasma cells: SDF-1, flt3L, and BAFF. (2007) Mol. Immunol 44, 1617-1623.

45) Kasper G, Reule M, Tschirschmann M, Dankert N, Stout-Wieder K, Lauster R, Schrock E, Mennerich D, Duda G.N, Lehmann K.E. ST-3 over-expression enhances tumourigenesis in MCF-7 and MDA-MB-231 breast cancer cell lines: involvment of the IGF-1 singalling pathway, (2007) BMC cancer 7:12

46) Aguilar Romanillos, A et al. En Route to the Knowledge-Based Bio-Economy, “Cologne Paper” by the EU Commission for Biotechnology, presented at the Bioperspectives, May 2007, Cologne

47) Nogai H, Rosowski,M, Grün J, Rietz A,, Debus N, Schmidt G, Lauster C, Janitz M, Vortkamp A, Lauster R Follistatin antagonizes TGF-β3-induced epithelial-mesenchymal transition in vitro: Implications for murine palatal development supported by microarray analysis. (2008) Differentiation. 76:404-16.

48) Reutter H, Birnbaum S, Mende M, Lauster C, Schmidt G, Henschke H, Saffar M, Martini M, Lauster R, Schiefke F, Reich RH, Braumann B, Scheer M, Knapp M, Nöthen MM, Kramer FJ, Mangold E. TGFB3 displays parent-of-origin effects among central Europeans with nonsyndromic cleft lip and palate. (2008) J Hum Genet. 53:656-61.

49) Kemp C, Thiele H, Dankof A, Schmidt G, Lauster C, Fernahl G and Lauster R. Cleft lip and/or palate with monogenic autosomal recessive transmission in pyrenees shepherd dogs (2009) Cleft Palate Craniofac J. 46:81-8.

50) Havlickova B, Biro T, Mescalchin A, Tschirschmann M, Mollenkopf H, Bettermann A, Pertile P, Lauster R, Paus R. A novel human follocoid microshere assay for exploring epithelial-mesenchymal interactions that mimic intrafollicular communication pathways (2009) J Invest Dermatol. 129:972-83.

51) Dehne T, Tschirschmann M, Lauster R, Sittinger M. Regenerative potential of human adult precursor cells : Cell therapy - an option for treating cartilage defects](2009) Z. Rheumatol. 68:234-8.

52) Winter H, Holmer C, Buhr HJ, Lindner G, Lauster R, Kraft M and Ritz JP. Pilot study of bipolar radiofrequency-induced anastomotic thermofusion–exploration of therapy parameters ex vivo. (2010) Int. J.Colorectal Disease 25:129-133.

53) Sonntag F, Schilling N, Mader K, Gruchow M, Klotzbach U, Lindner G, Horland R, Wagner I, Lauster R, Howitz S, Hoffman S Marx U. Design and prototyping of a chip-based multi-micro-organoid culture system for substance testing, predictive to human (substance) exposure. (2010) J. Biotechnol. 148: 70-75.

54) Ariza de Schellenberger A, Horland R, Rosowski M, Paus R, Lauster R, Lindner G: Cartilage oligomeric matrix protein (COMP) forms part of the connective tissue of normal human hair follicles (2011) J. Exp. Dermatol. 20, 361-366.

55) Holmer C, Winter H, Kröger M, Nagel A, Jaenicke A, Lauster R, Kraft M, Buhr HJ, Ritz JP. Bipolar radiofrequency-induced thermofusion of intestinal anastomoses-feasibility of a new anastomosis technique in porcine and rat colon. (2011) Langenbecks Arch Surg.

56) Lindner G, Horland R, Wagner I, Ataç B, Lauster R. De novo formation and ultra-structural characterization of a fiber-producing human hair follicle equivalent in vitro. (2011) J. Biotechnol. 152: 108-112.


57) Horland R, Lindner G, Wagner I, Atac B, Hoffmann S, Gruchow M, Sonntag F, Klotzbach U, Lauster R, Marx U. Human hair follicle equivalents in vitro for transplantation and chip-based substance testing. (2011) BMC Proc. 22;5 Suppl 8:O7

58) Blanchard V, Liu X, Eigel S, Kaup M, Rieck S, Janciauskiene S, Sandig V, Marx U, Walden P, Tauber R, Berger M. N-glycosylation and biological activity of recombinant human alpha1-antitrypsin expressed in a novel human neuronal cell line. (2011) Biotechnol Bioeng. 108:2118-28

59) Kröger M, Jaenicke A, Winter H, Nagel A, Buhr HJ, Ritz JP, Lauster R, Kraft M, Holmer C. Reduction of thermal tissue damage caused by bipolar radiofrequency-induced thermofusion. (2011) Biomed Tech  Aug.

60) Marx U, Walles H, Hoffmann S, Lindner G, Horland R, Sonntag F, Klotzbach U, Sakharov D, Tonevitsky A, Lauster R. 'Human-on-a-chip' developments: a translational cutting-edge alternative to systemic safety assessment and efficiency evaluation of substances in laboratory animals and man? (2012) Altern Lab Anim. 40(5):235-57.

61)Kröger M, Jaenicke A, Winter H, Nagel A, Buhr HJ, Ritz JP, Lauster R, Kraft M, Holmer C.Reduction of thermal tissue damage caused by bipolar radiofrequency-induced thermofusion. (2012) Biomed Tech Aug.

62) Busek M, Polk C, Albrecht T, Marx U, König J, Sonntag F. Automated Micro-PIV measurement in Lab-on-a-Chip systems. (2012) Biomed Tech Aug

63) Seifert M, Lubitz A, Trommer J, Könnig D, Korus G, Marx U, Volk HD, Duda G, Kasper G, Lehmann K, Stolk M, Giese C. Crosstalk between immune cells and mesenchymal stromal cells in a 3D bioreactor system. (2012) Int J Artif Organs. 11, 986-95

64) Marx U. Trends in cell culture technology. (2012) Adv Exp Med Biol.745:26-46

65) Schimek K, Busek M, Brincker S, Groth B, Hoffmann S, Lauster R, Lindner G, Lorenz A, Menzel U, Sonntag F, Walles H, Marx U, Horland R. Integrating biological vasulature into a multi-organ-chip microsystem. (2013) Lab Chip 13, 3588-98

66) Materne EM, Tonevitsky AG, Marx U. Chip-based liver equivalents for toxicity testing - organotypicalness versus cost-efficient high throughput. (2013) Lab Chip. 13, 3481-95

67) Wagner I, Materne EM, Brincker S, Süßbier U, Frädrich C, Busek M, Sonntag F, Sakharov DA, Trushkin EV, Tonevitsky AG, Lauster R, Marx U. A dynamic multi-organ-chip for long-term cultivation and substance testing proven by 3D human liver and skin tissue co-culture. (2013) Lab Chip. 13, 3538-47

68) Ataç B, Wagner I, Horland R, Lauster R, Marx U, Tonevitsky AG, Azar RP, Lindner G. Skin and hair on-a-chip: in vitro skin models versus ex vivo tissue maintenance with dynamic perfusion. (2013) Lab Chip. 13, 3555-61

69) Sergachev I, Rusanov A, Trushkin E, Sakharov D, Marx U, Tonevitsky A. Fluorescent optical fiber sensors for cell viability monitoring. (2013) Analyst. 17;138, 14

70) Tykwinska K, Lauster R, Knaus P, Rosowski M. Growth and differentiation factor 3 induces expression of genes related to differentiation in a model of cancer stem cells and protects them from retinoic Acid-induced apoptosis (2013) PLoS One, 8(8)

71) Giese, C and Marx, U. Human immunity in vitro - Solving immunogenicity and more (2014). Adv Drug Deliv Rev.

72) Dehne T, Adam X, Materne EM, Reimann MC, Krüger JP, VanLinthout S, Tschöpe C, Haag M, Sittinger M, Ringe J. A P19 and P19CL6 Cell-Based Complementary Approach to Determine Paracrine Effects in Cardiac Tissue Engineering (2014) Cell Tissue Organs 199: 24-36

73) Materne EM, Ramme AP, Terrasso AP, Serra M, Alves PM, Brito C, Sakharov DA, Tonevitsky AG, Lauster R, Marx U. A multi-organ chip co-culture of neurospheres and liver equivalents for long-term substance testing. (2015) J Biotechnol. Feb.

74) Maschmeyer I, Hasenberg T, Jaenicke A, Lindner M, Lorenz AK, Zech J, Garbe LA, Sonntag F, Hayden P, Ayehunie S, Lauster R, Marx U, Materne EM. Chip-based human liver-intestine and liver-skin co-cultures - A first step toward systemic repeated dose substance testing in vitro. (2015) Eur J Pharm Biopharm. April

75) Materne EM, Maschmeyer I, Lorenz A, Horland R, Schimek K, Busek M, Sonntag F, Lauster R, Marx U. The Multi-organ Chip - A Microfluidic Platform for Long-term Multi-tissue Coculture. (2015) J. Vis. Exp. 98, e52526,

76) Maschmeyer I, Lorenz A, Schimek K, Hasenberg T, Ramme A, Hübner J, Lindner M, Drewell C, Bauer S, Thomas A, Sambo NS, Sonntag F, Lauster R and Marx U. A four-organ-chip for interconnected long-term co-culture of human intestine, liver, skin and kidney equivalents (2015) Lab on a chip, May

77) Drzymala SS, Binder J, Brodehl A, Penkert M, Rosowski M, Garbe LA, Koch M. Estrogenicity of novel phase I and phase II metabolites of zearalenone and cis-zearalenone. (2015) Toxicon 105:10-12

78) Wagner A, Röhrs V, Materne EM, Hiller T, Kedzierski R, Fechner H, Lauster R, Kurreck J. Use of a three-dimensional humanized liver model for the study of viral gene vectors (2015) J Biotechnol. 212:134-143

79) Hasenberg T, Mühleder, S, Dotzler, A, Bauer, S, Labuda, K, Holnthoner, W, Redl, H, Lauster, R and Marx, U. Emulating Human Microcapillaries in a Multi-Organ-Chip Platform (2015) J Biotechnol. in press








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